Gephyrin is the best characterized GlyR-interacting protein. Biochemical characterization and heterologous expression have shown that gephyrin binds cooperatively to tubulin dimers with a high affinity, and to GlyR via an 18-amino-acid sequence in the β subunit M3–M4 cytoplasmic loop. Here, we investigated the properties of gephyrin scaffolds at γ-aminobutyric acid- (GABA-)ergic synapses in organotypic entorhino-hippocampal cultures prepared from a transgenic mouse line, which expresses green fluorescent protein-tagged gephyrin under … Sequences of the binding sites for Pin1 (Zita et al., 2007), Dlc1/2 (Fuhrmann et al., 2002) and collybistin (Kins et al., … Biochemical studies have shown that gephyrin molecules form stable trimers through interactions of their G-domains and that they can dimerize via their E-domains (Schrader et al, 2004; Sola et al, 2004; Saiyed et al, 2007). DEFINITION . Gephyrin is the major instructive molecule at inhibitory synapses, where it clusters glycine as well as major subsets of GABA type A receptors (GABA A Rs). Definition of gephyrin in the Definitions.net dictionary. Break 'zephyr' down into sounds: [ZEF] + [UH] - say it out loud and exaggerate the sounds until you can consistently produce them. The average size differences resulted from changes in the proportions of small and large gephyrin clusters. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157). The impact of the gephyrin S270A mutation on gephyrin cluster area and intensity was more pronounced, in comparison to the S268E mutant. Definition of Geotropic. “A positive correlation between gephyrin puncta and PV bouton numbers per cell might suggest these synaptic markers might be related if not spatially coupled.” 8. Gephyrin was initially identified by its interaction with the glycine receptor, but more recent work has shown that it also interacts and recruits subunits of GABA A Rs (Wang et al., 1999; Combs and Markman, 2014). (2013) report in this issue of Neuron on the quantitative assessment of gephyrin clusters and associated glycine receptors and GABAA receptors. Molybdopterin with MoO 4 − 2 coordinated to the dithiolen of the side chain is the essential cofactor of at least six human enzymes. In an attempt to identify additional components of inhibitory postsynaptic specializations, we performed a yeast two-hybrid screen using gephyrin as bait. Define gephyrophobia. Alzheimer's disease (AD) is currently incurable, but there is general agreement that a minimally invasive blood biomarker for screening in preclinical stages would be crucial for future therapy. Gephyrin knock-out mice show a phenotype resembling both defective glycinergic transmission and molybdenum cofactor (Moco) deficiency and die within 1 day of … Gephyrin mediates the postsynaptic clustering of glycine receptors (GlyRs) and GABAA receptors at inhibitory synapses and molybdenum-dependent enzyme (molybdoenzyme) activity in non-neuronal tissues. Anxiety disorders are the most prevalent mental illnesses in the U.S. and are estimated to consume one-third of the country’s mental health treatment cost. [G. gephyra, bridge, + phobos, fear] Here, we exploited superresolution techniques combined with proximity-based clustering analysis and model simulations to investigate the single-molecule gephyrin reorganization during plasticity of inhibitory synapses in mouse hippocampal cultured neurons. Diagnostic tools for detection of AD are either invasive like … Relating to, or showing, geotropism. "The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse." Abstract. ¹. Definition of Geotropic. This protein, named gephyrin (from the Greek gamma epsilon phi upsilon rho alpha, … Here are 4 tips that should help you perfect your pronunciation of 'zephyr':. Gephyrin also binds collybistin (CB) and neuroligin 2 (NL2), that has been proposed to function as a specific activator of collybistin. Below you will find example usage of this term as found in modern and/or classical literature: 1. Neurexin and neuroligin also play a role in angiogenesis.. Neurexins and neuroligins, which are transmembrane synaptic proteins of the central nervous … Gephyrin. We found that the density of dendritic Teal-gephyrin puncta ... GABAergic dendritic synapses can be frequently formed and eliminated in the same location, leading to a new definition of inhibitory synaptic plasticity that relies on substantial, dynamic rearrangements of GABAergic synapses (Chen et al., 2012. Rapsyn, gephyrin, and PSD-95 as scaffolding proteins and signaling molecules. Receptor recruitment to inhibitory GABAergic and glycinergic synapses is controlled by the scaffold protein gephyrin and the adaptor protein … Startle disease is a rare disorder associated with mutations in GLRA1 and GLRB, encoding glycine receptor (GlyR) α1 and β subunits, which enable fast synaptic inhibitory transmission in the spinal cord and brainstem. Gephyrin was identified by its interaction with the glycine receptor, the main receptor protein of inhibitory synapses in the spinal cord and brainstem. Clustering of the GABA-A receptor chloride channel alters receptor pharmacology on the cell surface and reduced clustering of the GABA receptor is associated with anxiety. Gephyrin is a key scaffold protein mediating the anchoring of GABAA receptors at inhibitory synapses. Recently, gephyrin was shown to interact with RAFT1, a DNA-activating protein kinase. Practical Text-book of Plant Physiology by Daniel Trembly Macdougal (1912) "Recovery from a Position Assumed geotropically. Zephyrin Spelling And The Sound Of Letter Pronunciations Name Zephyrin syllable is: ze-phy-rin (we separated the syllables with dashes). Literary usage of Geotropically. Anti-Gephyrin Antibody (G-6) is recommended for detection of Gephyrin of mouse, rat and human origin by WB, IP, IF, IHC (P) and ELISA. Gephyrin interacts directly with KIF5 and GlyRs, and the gephyrin/KIF5/GlyR complex moves in anterograde directions toward the plus ends of microtubules. Gephyrin is a key scaffold protein mediating the anchoring of GABAA receptors at inhibitory synapses. gephyrins. Molybdenum is a chemical element with the symbol Mo and atomic number 42. It consists of an N-terminal G-domain and a C-terminal E-domain, which are connected by a central region composed of ∼160 amino-acid residues. Learn how to pronounce Zephyrine Zephyrine Rate the pronunciation difficulty of Zephyrine 3 /5 (69 votes) Very easy Easy Moderate Difficult Very difficult Pronunciation of Zephyrine with 8 … 1. a. 60. See also: Travel -Ologies & -Isms. Gephyrin is a 93 kDa cytoplasmic protein, which was initially discovered through copurification with GlyRs from rat spinal cord (Pfeiffer et al, 1982). See also: Travel -Ologies & -Isms. Definition The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Using next-generation … Lexicographical Neighbors of Geraniols. Gephyrin, which is crucial for the stabilization of postsynaptic GlyR microdomains, is present in mature neurons at postsynaptic differentiations. Quantification for eGFP-gephyrin cluster density (Nb), cluster size (area), and intensity (Int) showed a tendency for reduced clustering for the S268E mutant and increased clustering for the S270A mutant (Fig 1B). We investigated whether the expression of glycinergic receptor (GLYR) subunits of gephyrin and of their mRNAs in the medial vestibular nuclei are affected following unilateral labyrinthectomy. plural of gephyrin; Anagrams []. No ectopic GlyRβ clusters were detected, meaning that GlyRs and gephyrin always colocalized (Figure 4—figure supplement 1). gephyrin. Gephyrin is a postsynaptic, scaffolding protein anchoring type A GABA and glycine receptors to the cytoskeleton. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Gephyrin is the first postsynaptic scaffolding protein ever discovered and it was recently found to display a large degree of variation and regulation by splice variants, posttranslational modifications, intracellular trafficking and interactions with the underlying cytoskeleton. Arrows point to nonsynaptic gephyrin clusters upon incubation with 2-BP. Upload it here to share it with the entire community. Z - zuh E - eh, ee, silent P - puh H - huh, silent Y - yuh, ee, ah-ee (i), ĭ R - ruh, ur I - ah-ee, ĭ N - nuh Zephyrin Pronunciation In English These names are examples to help you learn. Gephyrin (736 aa, ~80 kDa) is encoded by the human GPHN gene. As expected, eGFP-DN failed to cluster (data not shown). Proper usage and audio pronunciation (plus IPA phonetic transcription) of the word molybdenum. Gephyrin is the main scaffold protein at inhibitory synapses and a key player for both GlyR and GABA A R clustering. Gephyrin therefore has been … Gerund. Se-quence analysis of gephyrin indicates that it originated from a Palmitoylation of gephyrin is essential for clustering at GABAergic synapses. gephyrophobia synonyms, gephyrophobia pronunciation, gephyrophobia translation, English dictionary definition of gephyrophobia. (biology) Of or pertaining to geotropism. Page 8 line 237, please define “SEM image”. Anti-Gephyrin Antibody (G-6) is a mouse monoclonal IgG 2b κ Gephyrin antibody, cited in 11 publications, provided at 200 µg/ml. Nonetheless, resolving the molecular interactions between the plethora of GABAAR subunits and these clustering proteins is a significant challenge. Gephyrin and collybistin are key components of GABA A receptor (GABA A R) clustering. Annotation score: Annotation score:1 out of 5. Gamma-amino butyric acid (GABA) is an inhibitory neurotransmitter that acts at synapses through binding to ligand-gated ion channels, the GABA receptors. Functional receptors of this family comprise five subunits and are important targets for neuroactive drugs. Gephyrin is the best characterized GlyR-interacting protein. Gephyrin trimers are believed to aggregate into a submembranous lattice that provides stability to postsynaptic GABA A Rs. Jump to navigation Jump to search. Learn how to pronounce Zephyrinus Zephyrinus Rate the pronunciation difficulty of Zephyrinus 5 /5 (1 Vote) Very easy Easy Moderate Difficult Very difficult Pronunciation of Zephyrinus with 1 audio pronunciations 0 rating Record the pronunciation of this word in your own voice and play it to listen to how you have pronounced it. Here, we exploited superresolution techniques combined with proximity-based clustering analysis and model simulations to investigate the single-molecule gephyrin reorganization during plasticity of inhibitory synapses in mouse hippocampal cultured neurons. Abstract. Sign Up as Researcherto review it or Suggest for a Review Compose your Definition Advisory Board Distribution of Gephyrin in Normal Adult Rat Dentate Gyrus: Layer-specific Localization of Gephyrin. By x-ray crystallography and cross-linking, the N-terminal G-domain of gephyrin has been shown to form trimers and the C-terminal E-domain dimers, respectively. Here, we identified palmitoylation of gephyrin as an important mechanism of strengthening GABAergic synaptic transmission, which is regulated by GABA A R activity. Gephyrin definition: Collins Dictionary Definition | Meaning, pronunciation, translations and examples The figure caption has been updated to include the definition for the SEM acronym. raised against amino acids 437-736 of Gephyrin of human origin. A neurexin (NRXN) is a presynaptic protein that helps to make connections between neurons at the synapse. Gephyrin is the major instructive molecule at inhibitory synapses, where it clusters glycine as well as major subsets of GABA type A receptors (GABA A Rs). “A positive correlation between gephyrin puncta and PV bouton numbers per cell might suggest these synaptic markers might be related if not spatially coupled.” 8. The GlyR β subunit is important for synaptic localization via interactions with gephyrin and contributes to agonist binding and ion channel conductance. The formation of neuronal synapses and the dynamic regulation of their efficacy depend on the assembly of the postsynaptic neurotransmitter receptor apparatus. The name is from Neo-Latin molybdaenum, which is based on Ancient Greek Μόλυβδος molybdos, meaning lead, since its ores were confused with lead ores. Gephyrin immunoreactivity was examined over the surface of neurons of the ventral horn in lumbar spinal cord sections (150–300 μm), in rats aged 10–15 days postnatal. Nonetheless, resolving the molecular interactions between the plethora of GABA A R sub- english (1124) hebrew (832) greek (730) arabic (570) german (570) latin (489) Jump to navigation Jump to search. Gephyrin is the first postsynaptic scaffolding protein ever discovered and it was recently found to display a large degree of variation and regulation by splice variants, posttranslational modifications, intracellular trafficking and interactions with the underlying cytoskeleton. 1. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses. girl (6265) boy (4886) unisex (1558) Starts with. Abstract. This protein is involved in biosynthesis of the molybdenum cofactor. Lexicographical Neighbors of Geranial. Gephyrin and collybistin are key components of GABAA receptor (GABAAR) clustering. Quantification for eGFP-gephyrin cluster density (Nb), cluster size (area), and intensity (Int) showed a tendency for reduced clustering for the S268E mutant and increased clustering for the S270A mutant (Fig 1B). Contains . Gephyrin constructs. In many brain regions, gephyrin and GABA A receptor clustering at developing inhibitory synapses depends on the guanine nucleotide exchange factor collybistin (Cb). Purpose: Gephyrin (GPHN) is an essential protein in the regulation of inhibitory postsynaptic density and polymorphism in the corresponding gene may have a role in the development of pharmacoresistant epilepsy (PRE). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). Page 8 line 237, please define “SEM image”. (abbreviation) He was educated at Reims and Paris, and spent several years in England and Ger many. Pronounce Zephyrine in Spanish (Mexico) view more / help improve pronunciation. Definition of Geraniols. Gephyrin is an extensively studied scaffolding protein at inhibitory synapses. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses. Although anxiolytic therapies are available, many patients still exhibit treatment resistance, relapse, or substantial side effects. Definition from Wiktionary, the free dictionary. gephyrophobia synonyms, gephyrophobia pronunciation, gephyrophobia translation, English dictionary definition of gephyrophobia. Turkish Pronunciation: Welsh Pronunciation: Ukrainian Pronunciation: Have a better pronunciation ? an abnormal fear of crossing bridges. 2012).It is well established as a major scaffolding protein for the organization of inhibitory glycine receptors (GlyRs) and type A GABA receptors (GABA A Rs) at postsynaptic sites (Tyagarajan and Fritschy 2014) in precise apposition to … 1. geraniol [n] - See also: geraniol. A 93 kd polypeptide associated with the mammalian inhibitory glycine receptor (GlyR) is localized at central synapses and binds with high affinity to polymerized tubulin. Molybdenum minerals have been known throughout history, but the element was discovered (in the sense of differentiating it as a new entity from the … We report a direct interaction of GABAAR α2 and α3 subunit intracellular M3–M4 domain (but not α1, α4, α5, α6, β1–3, or γ1–3) with gephyrin. Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. Both the immediate precursors and the cofactor itself are unstable unless associated with an enzyme. gephyrophobia: ( jef'ī-rō-fō'bē-ă ), Fear of crossing a bridge. 1. citral [n -S] - See also: citral. qRT-PCR experiments revealed no difference in gephyrin (p = 0.206), γ2, or control GABA A R β3 subunit mRNA levels between vehicle and DZP treated neurons ().To determine if post-translational modification of γ2 also occurs coincident with decreased γ2 … Gephyrin is a scaffolding protein important for the postsynaptic clustering of inhibitory neurotransmitter receptors. Utilizing localization microscopy, Specht et al. Definition from Wiktionary, the free dictionary. The vast majority of Cb splice variants contain an autoinhibitory src homology 3 domain, and several synaptic proteins are known to bind to this SH3 domain and to thereby activate gephyrin … Search Result : 6252 hits Entry KO len SW-score(margin) bits identity overlap best(all) ----- ----- mcc:709677 gephyrin K15376 736 4851 ( 4711) 1112 1.000 736 <-> 21 rno:64845 gephyrin K15376 736 4848 ( 4704) 1111 0.999 736 <-> 19 gga:428878 gephyrin K15376 736 4841 ( 4717) 1109 0.997 736 <-> 11 loc:102688656 gephyrin isoform X12 K15376 736 4781 ( 4669) 1096 … syphering Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. ARHGEF9 mutations have been identified in patients with heterogeneous phenotypes, including epilepsy of variable severity and intellectual disability. Gephyrin is a highly evolutionarily conserved protein with multiple functions in neuronal and non-neuronal cells (Nawrotzki et al. In addition to gephyrin’s function clustering synaptic neurotransmitter receptors, it plays an essential role in the biosynthesis of the molybdenum cofactor (MoCo). This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. Describes the response of plants toward the pull of gravity. After TeNT injections, the average gephyrin cluster areas on Renshaw cells increased by 18.4% at P15 and 28.4% at P20 and decreased after BoNT-A injections by 17.7% at P15 and 19.9% at P20. Definition of molybdenum in the AudioEnglish.org Dictionary. Neurexins (located presynaptically) act as receptors for neuroligin (located postsynaptically). This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine receptor family of ligand-gated ion channels. Here, we investigated the properties of gephyrin scaffolds at γ-aminobutyric acid- (GABA-)ergic synapses in organotypic entorhino-hippocampal cultures prepared from a transgenic mouse line, which expresses green fluorescent protein-tagged gephyrin under … Abstract. Using tandem mass spectrometry (MS/MS) analysis of native gephyrin isolated from adult mouse brain homogenate by immunoprecipitation, we identified a phosphopeptide, with Ser270 as a unique phosphorylation site (Materials and Methods).To study the relevance of Ser270 phosphorylation for gephyrin … However, the mechanism underlying phenotype variation is unknown. Further, due to the COVID-19 pandemic and stay-at-home order, social isolation, fear of … Gephyrin is a bifunctional modular protein that, in neurons, clusters glycine receptors and γ-aminobutyric acid, type A receptors in the postsynaptic membrane of inhibitory synapses. Single labeling for gephyrin in sections prepared from cryo-fixed and perfusion-fixed brains showed a difference in staining intensity (Figs 3, 5) which was reported for the mAb 7a antibody in other systems (Kirsch and Betz, 1993). Gephi pronunciation - How to properly say Gephi. The mEos4b/gephyrin-7a ratio was relatively equal across the spinal cord with greater variation seen in oscillator. Gephyrin is a bi-functional modular protein involved in molybdenum cofactor biosynthesis and in postsynaptic clustering of inhibitory glycine receptors (GlyRs). Leave a vote for your preferred pronunciation. English Etymology . Define gephyrophobia. Definition of Geotropic. Download scientific diagram | Shank1 deficit causes reduced E-I ratio by reducing inhibitory synaptic function and gephyrin expression (A) Shank1 … Gephyrin also binds collybistin (CB) and neuroligin 2 (NL2), that has been proposed to function as a specific activator of collybistin. In cells, gephyrin appears to form oligomers of at least three subunits. Several splice variants have been described that prevent this oligomerization without influencing the affinity for receptors. They nevertheless affect the composition of inhibitory synapses and can even play a role in diseases like epilepsy. 9. ¹ Source: wiktionary.com. 9. Next we assessed if the decrease in gephyrin and γ2 total levels at 24 h was a result of altered gene expression. The impact of the gephyrin S270A mutation on gephyrin cluster area and intensity was more pronounced, in comparison to the S268E mutant. (a) Immunostaining of gephyrin (red) and VGAT (green) in primary hippocampal neurons. For the first time, we aimed to evaluate the association of rs928553T/C variants with PRE susceptibility. Insets are taken from 20 µm dendritic segments. Definition of Geranial. Gephyrin trimers are believed to aggregate into a submembranous lattice that provides stability to postsynaptic GABA A Rs. Here, we identified palmitoylation of gephyrin as an important mechanism of strengthening GABAergic synaptic transmission, which is regulated by GABA A R activity. Meaning of molybdenum. In many brain regions, gephyrin and GABA A receptor clustering at developing inhibitory synapses depends on the guanine nucleotide exchange factor collybistin (Cb). (A) Schematic depiction of the three gephyrin domains (G, C, E): the N-terminal G-domain (G) and the -terminal E-domain (E) are separated by a central C-domain (C). English [] Noun []. Scale bar, 20 µm. an abnormal fear of crossing bridges. Identifying Unique Phosphorylation Sites on Gephyrin. Definition The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Listen to the audio pronunciation in several English accents. Specific radioactive oligonucleotide probes recognizing the sequences encoding α1–3 and ß subunits of GLYR and the anchoring protein gephyrin were used to probe sections of … We found that the density of dendritic Teal-gephyrin puncta ... GABAergic dendritic synapses can be frequently formed and eliminated in the same location, leading to a new definition of inhibitory synaptic plasticity that relies on substantial, dynamic rearrangements of GABAergic synapses (Chen et al., 2012. At all ages examined, punctate gephyrin-ir clusters were found over the soma and dendrites of both motoneurons and interneurons. The GlyR is best known for mediating inhibitory neurotransmission in the spinal cord and brain stem, although recent … This allele, which encodes gephyrin protein, plays a role in both protein-cytoskeleton interactions and biosynthesis of the molybdenum cofactor. Manual assertion based on experiment in i. Ref.6. GPHN. 1. Then GlyR can enter and exit a gephyrin cluster based either on a receptor-gephyrin interaction (reaction k 3, k 4) or on a gephyrin-gephyrin interaction (reaction k −2). The figure caption has been updated to include the definition for the SEM acronym. Pronounce Zephyrine in Swedish view more / help improve pronunciation. Biochemical characterization and heterologous expression have shown that gephyrin binds cooperatively to tubulin dimers with a high affinity, and to GlyR via an 18-amino-acid sequence in the β subunit M3–M4 cytoplasmic loop. ; Record yourself saying 'zephyr' in full sentences, then watch yourself and listen.You'll be able to mark your mistakes quite easily. Simply select a language and press on the speaker button to listen to the pronunciation of the word. What does molybdenum mean? The C domain is magnified below. Ge(2) and ge(2,4,5) clones have been described previously (Meier et al., 2000b).Ge(2) corresponds to clone P1 (Prior et al., 1992).The construction of chimeric GlyR α1 βgb subunit, vege(2), mrfpge(2), vege(2,4,5), and mrfp(2,4,5) have been described previously (Meier et al., 2000b; Bedet et al., 2006).PCR fragments containing the G(2), E, and … The clustering of glycine receptors and major subtypes of GABAA receptors at inhibitory synapses is mediated by the tubulin-binding protein gephyrin. Adjective. Multiple positive clones encoded either the dynein light chain-1 … 1. Gephyrin is a protein that in humans is encoded by the GPHN gene. Kneussel M., Haverkamp S., Fuhrmann J.C., Wang H., Waessle H., Olsen R.W., Betz H. ARHGEF9 resides on Xq11.1 and encodes collybistin, which is crucial in gephyrin clustering and GABAA receptor localization. Figure 1. What does ger mean? Through this binding, gephy-rin is also involved in rapamycin-sensitive signaling (21). Meaning of gephyrin. Gephyrin also appears to be involved in the postsynaptic localization of major GABA A receptor subtypes (20). "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium." "The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells." [adj] Medical Definition of Geotropic. gephyrean gephyreans gephyrin gephyrins gephyrophobia gepirone ger gerah gerahs geraniaceous: geranial geranials geranine geraniol geraniol 10 … Information and translations of gephyrin in the most comprehensive dictionary definitions resource on the web. With immunofluorescence, discontinuous patches of gephyrin were detected within the neuronal soma of spinal cord neurons on the 1st day after plating. Gephyrin is a scaffolding protein important for the postsynaptic clustering of inhibitory neurotransmitter receptors. Gender. The impact of the gephyrin S270A mutation on gephyrin cluster area and intensity was more pronounced, in comparison to the S268E mutant. Gephyrin domains and structural organization. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Open Peer Review Review this DefinitionReview Definition Awaiting Peer Review No Reviews yet for this version. Molybdopterin synthesis from GTP and MoO 4 − 2 requires the cooperation of at least six distinct gene products (Figure 11.20), including … The vast majority of Cb splice variants contain an autoinhibitory src homology 3 domain, and several synaptic proteins are known to bind to this SH3 domain and to thereby activate gephyrin … Gephyrin is the key scaffolding molecule organizing the postsynaptic density at inhibitory synapses. Ends with. Language. The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. Information about molybdenum in …

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